original： 《Targeting the hallmarks of aging to improve influenza vaccine responses in older adults》 Abstract Age-related declines in immune responses pose significant challenges to defending against disease in later life. Influenza infection remains a major health burden in older adults, with survivors often experiencing substantial functional impairment. Despite the availability of vaccines designed specifically for […]

Objectives: Increasing evidence suggests that oxidative stress may play a key role in joint destruction due to rheumatoid arthritis (RA). The aim of this study was to elucidate the role of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that maintains the cellular defence against oxidative stress, in RA.Methods: The activation status of

The isothiocyanate sulforaphane (SF; 1-isothiocyanato-4(R)-methyl sulfinyl butane) is abundant in broccoli sprouts in the form of its glucosinolate precursor (glucoraphanin). SF is powerfully bactericidal against Helicobacter pylori infections, which are strongly associated with the worldwide pandemic of gastric cancer. Oral treatment with SF-rich broccoli sprouts of C57BL/6 female mice infected with H. pylori Sydney strain

Title：Simulated Digestion and Fermentation In Vitro by Obese Human Gut Microbiota of Sulforaphane from Broccoli Seeds Authors：Yifei Sun, Zhaocheng Tang, Tingting Hao, Zeyu Qiu, Baolong Zhang Affiliation：School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China Background：Sulforaphane is a kind of isothiocyanate, which is obtained by hydrolysis of glucosinolate by the unique myrosinase in

Author：Li J, Zhang Y, Wang L, et al. Year of publication：2024 Journal Information：Foods. 2024; 13(12): 2015. DOI：10.3390/foods13122015（The original text can be retrieved directly via DOI.） Key conclusions (English abstract excerpt)：“Sulforaphane, a natural isothiocyanate derived from cruciferous vegetables, exerts beneficial effects on high-fat-diet (HFD)-induced obesity in mice. It reduces adipose tissue accumulation, improves insulin sensitivity, and